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AuthorPfaffel-Schubart, Gesinedc.contributor.author
Date of accession2016-03-14T15:22:54Zdc.date.accessioned
Available in OPARU since2016-03-14T15:22:54Zdc.date.available
Year of creation2008dc.date.created
AbstractDuring photodynamic therapy (PDT) the interaction between light and photosensitizers induces oxidative stress and the production of reactive oxygen species (ROS). ROS formation influences ion channels and causes changes in the Ca²+ concentration which may induce further reactions leading to cell stimulation or cell death. In this study we analysed the influence of irradiation conditions on the cell death mechanisms during Hypericin-induced PDT. The process of apoptosis is characterised by morphological and physiological changes of the cell membrane and of the whole intracellular chain reactions. The translocation of the phospholipid phosphatidylserine from the inner to the outer leaflet of the plasma membrane is one of the earliest indications of apoptotic cell death. The translocation was traced by the binding of FITC (fluorescein isothiocyanate) conjugated Annexin-V to phosphatidilserine and FACS (fluorescence activated cell sorting) analysis.dc.description.abstract
Languagededc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandard (Fassung vom 01.10.2008)dc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v2dc.rights.uri
KeywordU373MG-Zellendc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHGlioblastomadc.subject.mesh
TitleWirkung von Hypericin-induzierter PDT auf die intrazelluläre Ca2+-Konzentration humaner Glioblastomzellendc.title
Resource typeDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-1551dc.identifier.doi
PPN590375008dc.identifier.ppn
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-66696dc.identifier.urn
GNDApoptosisdc.subject.gnd
GNDHypericindc.subject.gnd
GNDPhotodynamische Therapiedc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
Date of activation2009-01-20T12:31:21Zuulm.freischaltungVTS
Peer reviewneinuulm.peerReview
Shelfmark print versionZ: J-H 13.107; W: W-H 11.556uulm.shelfmark
DCMI TypeTextuulm.typeDCMI
VTS-ID6669uulm.vtsID
CategoryPublikationenuulm.category
University Bibliographyjauulm.unibibliographie


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