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Aktivitätsbestimmung des Morbus Crohn mittels Powerdopplersonographie: ein Vergleich mit der histopathologischen Aktivität

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vts_6640_9096.pdf (25.69Mb)
61 Seiten
Veröffentlichung
2008-12-29
Authors
Drews, Björn
Dissertation


Faculties
Medizinische Fakultät
Abstract
Objective: Retrospective comparison of semiquantitatively measured bowel wall vascularity, endoscopic-histopathological biopsy findings and disease activity in patients with confirmed Crohn’s disease. Patients and methods: Thirty-four of a total 1,332 patients with histologically confirmed Crohn’s disease (19 females, 15 males; mean age 37.8 years) met the following inclusion criteria: ileocolonoscopy with biopsy and power Doppler sonographic determination of bowel wall vascularity with assessment of disease activity within a period of five days. The sonographic determination of bowel wall vascularity was based on a semiquantitative score. The endoscopic bowel wall biopsy specimens were assessed using a self-developed inflammation score and the disease activity using the conventional Crohn’s Disease Activity Index (CDAI). Association was determined on the basis of the Kappa-coefficient, McNemar’s Test, logistic regression, sensitivity and specifity. Results: A significant association (p < 0.05) was shown for results of histology and bowel wall vascularity in the terminal ileum (Kappa = 0.66; sensitivity 95%; specificity 69%). There was no observed association between CDAI and histology although there was an association between CDAI and bowel wall vascularity (sensitivity 82%). Discussion: Increased bowel wall vascularity in the terminal ileum as demonstrated by power Doppler ultrasound is associated with histopathologically determined inflammatory activity.
Date created
2007
Subject headings
[GND]: Crohn-Krankheit
[MeSH]: Crohn disease | Ultrasonography
[Free subject headings]: Bowel wall | Disease activity
[DDC subject group]: DDC 610 / Medicine & health
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Standard (Fassung vom 01.10.2008)
https://oparu.uni-ulm.de/xmlui/license_v2

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DOI & citation

Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-1536

Drews, Björn (2008): Aktivitätsbestimmung des Morbus Crohn mittels Powerdopplersonographie: ein Vergleich mit der histopathologischen Aktivität. Open Access Repositorium der Universität Ulm und Technischen Hochschule Ulm. Dissertation. http://dx.doi.org/10.18725/OPARU-1536
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