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AuthorSchork, Mariondc.contributor.author
Date of accession2016-03-14T15:22:35Zdc.date.accessioned
Available in OPARU since2016-03-14T15:22:35Zdc.date.available
Year of creation2008dc.date.created
AbstractAn impairment of central somatosensory processing is assumed in restless legs syndrome (RLS). Although functional neuroimaging in RLS gave evidence to the presence of widespread functional changes in various brain areas, structural changes at the cortical level were not reported to be RLS-associated to date. Here, an analysis of high-resolution 3-dimensional magnetic resonance imaging (MRI) was performed in 63 patients with idiopathic RLS by use of optimized voxel-based morphometry, in order to investigate if sensorimotor and pain processing cortical areas might be altered in volume at group level according to the phenomenology of RLS. The comparison of the RLS patients versus controls yielded significant regional decreases of grey matter volume at corrected p < 0.05 in the bihemispheric primary somatosensory cortex which additionally extended into left-sided primary motor areas. All clusters correlated with the severity of RLS symptoms. These results, for the first time, give in vivo evidence to structural neocortical grey matter alterations in RLS patients. The alterations in the sensorimotor cortices might add to the pathophysiological concepts of idiopathic RLS.dc.description.abstract
Languagededc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandard (Fassung vom 03.05.2003)dc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v1dc.rights.uri
KeywordVoxel-basierte Morphometriedc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHRestless legs syndrome. Epidemiologydc.subject.mesh
MeSHSomatosensory cortexdc.subject.mesh
TitleKortikale Veränderungen bei Restless Legs Syndrom - eine Voxel-basierte morphometrische Untersuchungdc.title
Resource typeDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-1492dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-65536dc.identifier.urn
GNDRestless-legs-Syndromdc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
Date of activation2008-10-28T10:08:16Zuulm.freischaltungVTS
Peer reviewneinuulm.peerReview
Shelfmark print versionZ: J-H 13.084; W: W-H 11.536uulm.shelfmark
DCMI TypeTextuulm.typeDCMI
VTS ID6553uulm.vtsID
CategoryPublikationenuulm.category
Bibliographyuulmuulm.bibliographie


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