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AutorLiakos, Lambrosdc.contributor.author
Aufnahmedatum2016-03-14T15:22:32Zdc.date.accessioned
In OPARU verfügbar seit2016-03-14T15:22:32Zdc.date.available
Jahr der Erstellung2007dc.date.created
ZusammenfassungPre-clinical in vitro tests are needed to evaluate the biomechanical performance of new spinal implants. For such experiments large animal models are frequently used. Whether these models allow any conclusions concerning the implant´s performance in humans is difficult to answer. The aim of the present study was to investigate whether calf, pig or sheep spine specimens may be used to replace human specimens in in vitro flexibility and cyclic loading tests with two different implant types. First, a dynamic and a rigid fixator (tangoRS) were tested using six human, six calf, six pig and six sheep thoracolumbar spine specimens. Standard flexibility tests were carried out in a spine tester in flexion/extension, lateral bending and axial rotation in the intact state, after nucleotomy and after implantation. Then, the Wave-S Cage implant was tested for flexibility and sintering tendency using another six human and six calf lumbar spine segments. Loading was carried out as described above in the intact condition, after creation of a defect and after implantation. The fixators were most easily implantable into the calf. Qualitatively, they had similar effects on ROM in all species, however, the degree of stability achieved differed. Especially in axial rotation, the ROM of sheep, pig and calf was partially less than half the human ROM. Similarly, implantation of the Wave-S Cage caused the ROM to either increase in both species or to decrease in both of them, however, quantitatively, differences were observed. This was also the case for the sintering. In conclusion, animal species, especially the calf, may be used to get a first idea of how a new pedicle screw system or interbody cages behave in in vitro flexibility tests. However, the effects on ROM and intering tendency have to be expected to differ in magnitude between animal and human. Therefore, the last step in preclinical implant testing should always be an experiment with human specimens.dc.description.abstract
Sprachededc.language.iso
Verbreitende StelleUniversität Ulmdc.publisher
LizenzStandard (Fassung vom 03.05.2003)dc.rights
Link zum Lizenztexthttps://oparu.uni-ulm.de/xmlui/license_v1dc.rights.uri
SchlagwortCagesdc.subject
SchlagwortComparative spine implant testsdc.subject
SchlagwortPedicle screw systemdc.subject
DDC-SachgruppeDDC 610 / Medicine & healthdc.subject.ddc
MeSHSpinedc.subject.mesh
TitelEignung der Wirbelsäulen von Kalb, Schwein und Schaf für die In-vitro-Testung von Cages und Pedikelschraubensystemendc.title
RessourcentypDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-1480dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-65144dc.identifier.urn
GNDIn vitrodc.subject.gnd
GNDWirbelsäuledc.subject.gnd
FakultätMedizinische Fakultätuulm.affiliationGeneral
Quelle OriginalpublikationEur Spine J. 2007 Dec, 16(12):2186-92. Epub 2007 Aug 25uulm.citationOrigPub
Datum der Freischaltung2008-08-12T15:09:34Zuulm.freischaltungVTS
Peer-Reviewneinuulm.peerReview
Signatur DruckexemplarZ: J-H 11.912; W: W-H 11.397uulm.shelfmark
DCMI MedientypTextuulm.typeDCMI
VTS-ID6514uulm.vtsID
KategoriePublikationenuulm.category


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