|Abstract||To assess fronto-temporal cognitive functions and attention in RRMS patients compared to controls and to monitor the profile evolution under treatment conditions and without treatment. Methods: Multicenter study with a cross-sectional (CS) and follow-up (FO) module over 2 years. The CS module was entered by a total of 108 RRMS patients (30 m, 78 f, mean age 35.7 yr, McDonald criteria, disease duration < 3 yr, EDSS < 3.5) and 29 matched controls (11m, 18 f, mean age 33.5 yr). For the FO module, the RRMS group was splitted into 43 Avonex- and 45 Copaxone-treated patients and a non-treatment group (N = 20), the latter being reluctant to any immunmodulation. Neuropsychological (NP) and clinical assessment at baseline (CS) included: neurological status, EDSS, clinical global impression (CGI), ambulation index (AI), functional status (FS), fatigue severity scale (FSS), quality of life (EQ5d), executive functions (Regensburger word fluency test/RWT; Ruff figural fluency test/RFFT; color word interference test/CWIT; visual verbal test/VVT), working memory (Wechsler memory scale/WMS-R; digit and block spans/DS&BS backward; TAP battery for attention assessment, subtest working memory/TAPwm), learning and memory (recurring figures test/RFT; auditory verbal learning test/AVLT; WMS-R, subtests picture and story memory), attention/information processing (TAP, alertness/Tal; TAP, selective attention/Tsel; TAP, divided attention/Tdiv; paced auditory serial addition task/PASAT; complex figure Rey-Osterrieth/CFR).
Conclusion: The CS module of this study provides evidence for impaired fronto-temporal cognitive performance and specific attention dysfunctions early in the course of RRMS.||dc.description.abstract