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AuthorBochtler, Petradc.contributor.author
Date of accession2016-03-14T15:22:25Zdc.date.accessioned
Available in OPARU since2016-03-14T15:22:25Zdc.date.available
Year of creation2008dc.date.created
AbstractCD4 Foxp3 T cells are well-defined regulatory T (TR) cells that develop in the thymus through positive selection by medium-to-high affinity T cell receptor (TCR)-major histocompatibility (MHC) interactions. TR cells play an important role in autoimmunity, allergy, tumor immunity and organ transplantation. In the first part of this work, it is described that Foxp3 TR cells can be generated in the complete absence of MHC class II molecules. CD4 Foxp3 TR cells were found in lymph nodes, spleen, liver but not thymus of MHC class II-deficient (Aalpha-/-) C57BL/6J (B6) mice that were apparently generated in the periphery (inducible TR cells). These Foxp3 TR cells are preferentially expressing the cell surface molecule CD103 but not CD25 (that is highly expressed by thymus-dependent, natural TR cells). MHC class II-independent Foxp3 TR cells downmodulate T cell responses in vivo and in vitro with similar efficiency than those from congenic, wild-type B6 mice. Hence, Aalpha-/- mice are a novel model for the study of inducible Foxp3 TR cells. Only small populations of non-activated, non-proliferating Foxp3 TR cells are found in the non-parenchymal cell compartment of the mouse liver. Local increase of intrahepatic, regulatory CD4 Foxp3 TR cells is found in patients with chronic viral infection (i.e. hepatitis B virus or hepatitis C virus infection) or hepatocellular cancer. In the second part of this work, I show that specific or polyclonal T cell activation induces the accumulation of activated and proliferating regulatory T cells in the liver. Although it contains only a small, resident population of quiescent, local CD4 Foxp3 TR cells, the liver can hence rapidly mobilize and/or recruit this T cell control in response to the local accumulation of peripherally or locally activated CD8 T cells.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandard (Fassung vom 03.05.2003)dc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v1dc.rights.uri
KeywordCD4 Foxp3+ Tdc.subject
KeywordRegulatory T-cellsdc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHGenes, MHC class IIdc.subject.mesh
MeSHT-lymphocytes, regulatorydc.subject.mesh
TitleRegulatory mechanisms in immune responsesdc.title
Resource typeDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-1451dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-64708dc.identifier.urn
GNDImmunreaktiondc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
Date of activation2008-07-11T12:24:19Zuulm.freischaltungVTS
Peer reviewneinuulm.peerReview
Shelfmark print versionZ: J-H 11.894; W: W-H 11.382uulm.shelfmark
DCMI TypeTextuulm.typeDCMI
VTS-ID6470uulm.vtsID
CategoryPublikationenuulm.category
University Bibliographyjauulm.unibibliographie


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