Kontinuierliche Gewebeglucoseverläufe bei Gesunden als Basis für die Therapiesteuerung bei Diabetes mellitus
LicenseStandard (Fassung vom 03.05.2003)
Background: This study aimed to investigate continuous subcutaneous tissue glucose profiles in nondiabetic subjects. Methods: Continuous subcutaneous tissue glucose measurement was performed under everyday life conditions (2 days) and after ingestion of 4 meals with standardized carbohydrate content (50 g), but different types of carbohydrates and variable protein and fat content. Twenty-four healthy volunteers (12 female, 12 male, age 27.1 ± 3.6 years) participated in the study. Each study subject wore two microdialysis devices (SCGM1, Roche Diagnostics). Results: The mean 24 hour tissue glucose concentration under everyday life conditions was 89.3 ± 6.2 mg/dl (mean ± SD, n = 21), mean tissue glucose concentrations at daytime and during the night were 93.7 ± 7.0 and 81.8 ± 6.3 mg/dl, respectively. The highest postprandial glucose concentrations were observed after breakfast: 132.3 ± 16.7 mg/dl (range 101 - 168 mg/dl); peak concentrations after lunch and dinner were 118.2 ± 13.4 and 123.0 ± 16.9 mg/dl, respectively. After ingestion of standardized meals with fast resorption characteristics, peak tissue glucose concentrations were 133.2 ± 14.4 and 137.2 ± 21.1 mg/dl, respectively. Meals with a higher fibre, protein and fat content induced a smaller increase and a slower decrease of postprandial tissue glucose concentrations with peak values of 99.2 ± 10.5 and 122.1 ± 20.4 mg/dl, respectively. Time to peak glucose concentration was between 43 and 59 min. Conclusions: This study provides continuous tissue glucose profiles in nondiabetic subjects and demonstrates that differences in the meal composition are reflected in postprandial tissue glucose concentrations. Regarding the increasing application of continuous tissue glucose monitoring in diabetic patients, these data suggest that detailed information about the ingested meals is important for adequate interpretation of postprandial tissue glucose profiles.
Subject HeadingsLangzeit-Blutzuckermessung [GND]
Diabetes mellitus. Therapy [MeSH]
Glucose. Metabolism [MeSH]