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AuthorBühler, Andreasdc.contributor.author
Date of accession2016-03-14T15:22:13Zdc.date.accessioned
Available in OPARU since2016-03-14T15:22:13Zdc.date.available
Year of creation2007dc.date.created
AbstractWe analyzed the VH and VL gene rearrangements in 90 VH3-21+ patients from Sweden, Germany, Italy, USA, Finland and Australia and correlated these data with survival and other prognostic markers. Sixty-three percent exhibited mutated VH genes and 37 % unmutated VH genes. Fifty patients (56 %) displayed a short and homologous heavy-chain CDR3, many of these with the amino acid motif, DANGMDV. Also, a highly biased Vl2-14 usage was evident in 72% of patients with a restricted light-chain CDR3, QVWDS(S/G)SDHPWV. Combined restricted heavy- and light-chain CDR3s were found in patients from all included countries. Although VH3-21+ CLLs have a remarkably predominant l-expression, analyses of kappa deleting element indicated a conserved light-chain rearrangement order. The overall survival was poor in the VH3-21+ cohort (median survival 88 months) with no significant difference in relation to mutation status or CDR3 homology. High ZAP-70 and CD38 expression was found in both mutated and unmutated VH3-21+ cases as well as a slight increase of 11q- aberrations. In summary, highly restricted B-cell receptors and worse outcome characterize VH3-21+ CLLs independent of geographical origin and mutation status.dc.description.abstract
Languagededc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandard (Fassung vom 03.05.2003)dc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v1dc.rights.uri
KeywordIgVHdc.subject
KeywordIgVH-Rearrangementdc.subject
KeywordImmunglobulin-Schwerketten-Rearrangementdc.subject
KeywordVH3-21-Gendc.subject
KeywordVH-Mutationsstatusdc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHLeukemia, lymphatic, chronicdc.subject.mesh
MeSHPrognosisdc.subject.mesh
TitleHohe Strukturhomologie im Immunglobulin-Schwerketten-Rearrangement (IgVH) und ungünstiger Erkrankungsverlauf bei Patienten mit chronischer lymphatischer Leukämie (CLL) mit Umlagerung des VH3-21-Gens unabhängig von der geographischen Herkunft und dem VH-Mutationsstatusdc.title
Resource typeDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-1397dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-63765dc.identifier.urn
GNDChronisch-lymphatische Leukämiedc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
Date of activation2008-04-30T14:16:34Zuulm.freischaltungVTS
Peer reviewneinuulm.peerReview
Shelfmark print versionZ: J-H 11.851; W: W-H 11.340uulm.shelfmark
DCMI TypeTextuulm.typeDCMI
VTS-ID6376uulm.vtsID
CategoryPublikationenuulm.category


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