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AuthorLanzinger, Stefaniedc.contributor.author
AuthorRosenbauer, Joachimdc.contributor.author
AuthorSugiri, Dorotheadc.contributor.author
AuthorSchikowski, Tamaradc.contributor.author
AuthorTreiber, Birgitdc.contributor.author
AuthorKlee, Danieladc.contributor.author
AuthorRathmann, Wolfgangdc.contributor.author
AuthorHoll, Reinharddc.contributor.author
Date of accession2019-05-07T09:04:03Zdc.date.accessioned
Available in OPARU since2019-05-07T09:04:03Zdc.date.available
Date of first publication2018-02-24dc.date.issued
AbstractAims: Studies on the association between air pollution and metabolic control in children and adolescents with type 1 diabetes are rare and findings are inconsistent. We examined the relationship between particulate matter with an aerodynamic diameter <10 µm (PM10), nitrogen dioxide (NO2) and accumulated ozone exposure (O3-AOT) and HbA1c and daily insulin dose (IU/kg body weight) in children and adolescents with type 1 diabetes. Methods: We investigated 37,372 individuals with type 1 diabetes <21 years documented between 2009 and 2014 in 344 German centres of the diabetes prospective follow-up registry (DPV). Long-term air pollution exposure (annual and quinquennial means) was assigned to 5 digit postcode areas of residency. Cross-sectional multivariable regression analysis was used to examine the association between air pollution and metabolic control. Results: After comprehensive adjustment, an interquartile range increase in O3-AOT was associated with a lower HbA1c (-3.7% [95% confidence interval:-4.4, -3.0]). The inverse association between O3-AOT and HbA1c persisted after additional adjustment for degree of urbanization or additional adjustment for PM10. Moreover, the inverse association remained stable in further sensitivity analyses. No significant associations between HbA1c and PM10 or NO2 were found. No association was observed between any of the three air pollutants and insulin dose. Conclusions: The inverse association between O3-AOT and HbA1c could not be explained by regional differences in diabetes treatment or other differences between urban and rural areas. Furthermore, our results remained stable in sensitivity analyses. Further studies on the association between air pollution and HbA1c in children and adolescents with type 1 diabetes are needed to confirm our observed association and to elucidate underlying mechanisms.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandard (ohne Print-on-Demand)dc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_opod_v1dc.rights.uri
KeywordAir pollutiondc.subject
KeywordHbA1cdc.subject
KeywordMetabolic controldc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
LCSHAir; Pollutiondc.subject.lcsh
MeSHInsulinsdc.subject.mesh
MeSHOzone; Adverse effectsdc.subject.mesh
MeSHMetabolismdc.subject.mesh
MeSHParticulate matterdc.subject.mesh
MeSHDiabetes mellitus, Type 1dc.subject.mesh
MeSHGlycated hemoglobin Adc.subject.mesh
TitleImpact of long-term air pollution exposure on metabolic control in children and adolescents with type 1 diabetes: results from the DPV registrydc.title
Resource typeWissenschaftlicher Artikeldc.type
VersionacceptedVersiondc.description.version
DOIhttp://dx.doi.org/10.18725/OPARU-13993dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-14050-4dc.identifier.urn
GNDLuftverschmutzungdc.subject.gnd
GNDBlutbilddc.subject.gnd
GNDOzondc.subject.gnd
GNDFeinstaubdc.subject.gnd
GNDZuckerstoffwechseldc.subject.gnd
GNDDiabetes mellitus / Typ Idc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
InstitutionInstitut für Epidemiologie und Medizinische Biometrieuulm.affiliationSpecific
Peer reviewjauulm.peerReview
DCMI TypeTextuulm.typeDCMI
CategoryPublikationenuulm.category
In cooperation withGerman Centre for Diabetes Research (DZD), München-Neuherberguulm.cooperation
In cooperation withInstitute for Biometrics and Epidemiology, German Diabetes Centre, Leibniz Centre for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germanyuulm.cooperation
In cooperation withLeibniz Research Institute for Environmental Medicine (IUF), Düsseldorf, Germanyuulm.cooperation
In cooperation withHospital for Children and Adolescents, Clinical Centre St. Marien, Amberg, Germanyuulm.cooperation
In cooperation withPediatric Practice, Bürstadt, Germanyuulm.cooperation
Is Supplemented Byhttps://static-content.springer.com/esm/art%3A10.1007%2Fs00125-018-4580-8/MediaObjects/125_2018_4580_MOESM1_ESM.pdfuulm.relation.isSupplementedBy
DOI of original publication10.1007/s00125-018-4580-8dc.relation1.doi
Source - Title of sourceDiabetologiasource.title
Source - Place of publicationSpringersource.publisher
Source - Volume2018source.volume
Source - Issue6source.issue
Source - Year2018source.year
Source - From page1354source.fromPage
Source - To page1361source.toPage
Source - ISSN1432-0428source.identifier.issn
EU projectINNODIA / Translational approaches to disease modifying therapy of type 1 diabetes: an innovative approach towards understanding and arresting type 1 diabetes – Sofia ref.: 115797 / EC / H2020 / 115797uulm.projectEU
FundingGerman Centre for Diabetes Research (DZD)uulm.funding
FundingGerman Diabetes Association (DDG)uulm.funding
University Bibliographyjauulm.unibibliographie


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