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AuthorKleger, Alexanderdc.contributor.author
Date of accession2016-03-14T15:22:05Zdc.date.accessioned
Available in OPARU since2016-03-14T15:22:05Zdc.date.available
Year of creation2007dc.date.created
AbstractSphingosylphosphorylcholine (SPC) is the major component of high-density lipoproteins (HDL) in blood plasma. The bioactive lipid acts mainly via G protein coupled receptors (GPCRs). Similar to ligands of other GPCRs, SPC has multiple biological roles including the regulation of proliferation, migration, angiogenesis, wound healing and heart rate. Lysophospholipids and their receptors have also been implicated in cell differentiation. A potential role of SPC in stem cell or tumour cell differentiation has been elusive so far. Here we examined the effect of SPC on the differentiation of mouse embryonic stem (ES) cells and of human NB4 promyelocytic leukemia cells, a well established tumour differentiation model. Our data show that mouse embryonic stem cells and NB4 cells express the relevant GPCRs for SPC. We demonstrate both at the level of morphology and of gene expression that SPC induces neuronal and cardiac differentiation of mouse ES cells. Furthermore, SPC induces differentiation of NB4 cells by a mechanism which is critically dependent on the activity of the MEK-ERK cascade. Thus, the bioactive lipid SPC is a novel differentiation inducing agent both for mouse ES cells, but also of certain human tumour cells.dc.description.abstract
Languagededc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandard (Fassung vom 03.05.2003)dc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v1dc.rights.uri
KeywordMurine embryonale Stammzellendc.subject
KeywordSphingosylphosphorylcholinedc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHStem cellsdc.subject.mesh
TitleSphingosylphosphorylcholin induziert Differenzierung muriner embryonaler Stammzellen und humaner promyelozytärer Leukämiezellen.dc.title
Resource typeDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-1364dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-62815dc.identifier.urn
GNDEmbryonale Stammzelledc.subject.gnd
GNDLysophospholipidedc.subject.gnd
GNDPromyelozytenleukämiedc.subject.gnd
GNDZelldifferenzierungdc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
Date of activation2008-02-01T10:20:00Zuulm.freischaltungVTS
Peer reviewneinuulm.peerReview
Shelfmark print versionZ: J-H 11.732; W: W-H 9.932uulm.shelfmark
DCMI TypeTextuulm.typeDCMI
VTS-ID6281uulm.vtsID
CategoryPublikationenuulm.category
University Bibliographyjauulm.unibibliographie


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