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AuthorSchwandt, Ankedc.contributor.author
AuthorHermann, Julia M.dc.contributor.author
AuthorRosenbauer, Joachimdc.contributor.author
AuthorBoettcher, Claudiadc.contributor.author
AuthorDunstheimer, Desireedc.contributor.author
AuthorGrulich-Henn, Jürgendc.contributor.author
AuthorKuss, Oliverdc.contributor.author
AuthorRami-Merhar, Birgitdc.contributor.author
AuthorVogel, Christiandc.contributor.author
AuthorHoll, Reinharddc.contributor.author
Date of accession2019-04-25T11:32:04Zdc.date.accessioned
Available in OPARU since2019-04-25T11:32:04Zdc.date.available
Date of first publication2017-03-01dc.date.issued
AbstractOBJECTIVE: Worsening of glycemic control in type 1 diabetes during puberty is a common observation. However, HbA1c remains stable or even improves for some youths. The aim is to identify distinct patterns of glycemic control in type 1 diabetes from childhood to young adulthood. RESEARCH DESIGN AND METHODS: A total of 6,433 patients with type 1 diabetes were selected from the prospective, multicenter diabetes patient registry Diabetes-Patienten-Verlaufsdokumentation (DPV) (follow-up from age 8 to 19 years, baseline diabetes duration ≥2 years, HbA1c aggregated per year of life). We used latent class growth modeling as the trajectory approach to determine distinct subgroups following a similar trajectory for HbA1c over time. RESULTS: Five distinct longitudinal trajectories of HbA1c were determined, comprising group 1 = 40%, group 2 = 27%, group 3 = 15%, group 4 = 13%, and group 5 = 5% of patients. Groups 1-3 indicated stable glycemic control at different HbA1c levels. At baseline, similar HbA1c was observed in group 1 and group 4, but HbA1c deteriorated in group 4 from age 8 to 19 years. Similar patterns were present in group 3 and group 5. We observed differences in self-monitoring of blood glucose, insulin therapy, daily insulin dose, physical activity, BMI SD score, body-height SD score, and migration background across all HbA1c trajectories (all P ≤ 0.001). No sex differences were present. Comparing groups with similar initial HbA1c but different patterns, groups with higher HbA1c increase were characterized by lower frequency of self-monitoring of blood glucose and physical activity and reduced height (all P < 0.01). CONCLUSIONS: Using a trajectory approach, we determined five distinct longitudinal patterns of glycemic control from childhood to early adulthood. Diabetes self-care, treatment differences, and demographics were related to different HbA1c courses.dc.description.abstract
Languageendc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandard (ohne Print-on-Demand)dc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_opod_v1dc.rights.uri
KeywordGlycemic control trajectoriesdc.subject
KeywordCardiovascular risk-factorsdc.subject
KeywordImpactdc.subject
KeywordComplicationsdc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHAdolescentdc.subject.mesh
MeSHChilddc.subject.mesh
MeSHEuropean Continental Ancestry Groupdc.subject.mesh
MeSHProspective Studiesdc.subject.mesh
MeSHRegistriesdc.subject.mesh
MeSHYoung Adultdc.subject.mesh
MeSHRisk factorsdc.subject.mesh
MeSHBlood glucose; Metabolismdc.subject.mesh
MeSHDiabetes mellitus, Type 1; Therapydc.subject.mesh
MeSHBody-mass indexdc.subject.mesh
MeSHExercisedc.subject.mesh
MeSHMulticenter studiesdc.subject.mesh
MeSHInsulinsdc.subject.mesh
MeSHDiabetes complicationsdc.subject.mesh
MeSHGlycated hemoglobin A; Metabolismdc.subject.mesh
TitleLongitudinal trajectories of metabolic control from childhood to young adulthood in type 1 diabetes from a large German/Austrian registry: A groupbased modelling approachdc.title
Resource typeWissenschaftlicher Artikeldc.type
VersionacceptedVersiondc.description.version
DOIhttp://dx.doi.org/10.18725/OPARU-13828dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-13885-0dc.identifier.urn
GNDGlykämischer Indexdc.subject.gnd
GNDRisikofaktordc.subject.gnd
GNDBody-Mass-Indexdc.subject.gnd
GNDKörperliche Aktivitätdc.subject.gnd
GNDInsulindc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
InstitutionInstitut für Epidemiologie und Medizinische Biometrieuulm.affiliationSpecific
Peer reviewjauulm.peerReview
DCMI TypeTextuulm.typeDCMI
CategoryPublikationenuulm.category
In cooperation withInstitute for Biometrics and Epidemiology, German Diabetes Centre, Leibniz Centre for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germanyuulm.cooperation
In cooperation withDivision of Pediatric Endocrinology & Diabetology, Centre of Child and Adolescent Medicine, Justus Liebig University, Giessen, Germanyuulm.cooperation
In cooperation withDepartment of Pediatrics, Clinical Center Augsburg, Augsburg, Germanyuulm.cooperation
In cooperation withDepartment of Pediatrics, University of Heidelberg, Heidelberg, Germanyuulm.cooperation
In cooperation withDepartment of Pediatric and Adolescent Medicine, Medical University of Vienna, Vienna, Austriauulm.cooperation
In cooperation withDepartment of Pediatrics, Childrens’ Hospital Chemnitz, Chemnitz, Germanyuulm.cooperation
In cooperation withGerman Centre for Diabetes Research (DZD), München-Neuherberguulm.cooperation
DOI of original publication10.2337/dc16-1625dc.relation1.doi
Source - Title of sourceDiabetes Caresource.title
Source - Place of publicationAmerican Diabetes Associationsource.publisher
Source - Volume40source.volume
Source - Issue3source.issue
Source - Year2017source.year
Source - From page309source.fromPage
Source - To page316source.toPage
Source - ISSN0149-5992source.identifier.issn
Source - eISSN1935-5548source.identifier.eissn
EU projectINNODIA / Translational approaches to disease modifying therapy of type 1 diabetes: an innovative approach towards understanding and arresting type 1 diabetes – Sofia ref.: 115797 / EC / H2020 / 115797uulm.projectEU
FundingGerman Diabetes Association (DDG)uulm.funding
FundingFederal Ministry of Education and Research, German Competence Network for Diabetes mellitus, German Center for Diabetes Research (DZD) [01GI1106]uulm.funding
FundingThe Leona M. and Harry B. Helmsley Charitable Trustuulm.funding
FundingEFPIA companiesuulm.funding
FundingJDRFuulm.funding
Bibliographyuulmuulm.bibliographie
Is Supplemented Byhttp://care.diabetesjournals.org/content/suppl/2016/12/21/dc16-1625.DC1dc.relation.isSupplementedBy


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