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AuthorBurger, Andreasdc.contributor.author
Date of accession2016-03-14T15:22:00Zdc.date.accessioned
Available in OPARU since2016-03-14T15:22:00Zdc.date.available
Year of creation2006dc.date.created
AbstractMorphological evaluation of cerebrospinal fluid (CSF) samples by microscopy is still the method of choice for the detection of central nervous system involvement in patients especially with haematological malignancies. But, because morphological analysis of CSF in patients suspected of leptomeningeal involvement (LI) is false negative in one-third of patients, a supplementary diagnostic marker would be very valuable. The aim of this study was to examine the expression and value of the novel molecular indicator of malignancy called KOC (KH-domain containing protein overexpressed in cancer), a novel onco-foetal gene, at diagnosis of LI. 62 patients underwent lumbar puncture and CSF were examined by cytology and by a KOC RT-PCR assay. 43 patients (reactive changes in CNS, myeloid and lymphoid leukemias, lymphomas and solid tumours) with a clear cytology and KOC RT-PCR were included in this study. The expression of KOC showed a sensitivity of 60% and a specifity of 94%. The advantage of this method seems to be the good differentiation between malignant and reactive cells. Also the results at the immature leukemias and lymphomas are very interesting and further examinations should be done to prove the exact role of this new diagnostic tool.dc.description.abstract
Languagededc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandard (Fassung vom 03.05.2003)dc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v1dc.rights.uri
KeywordKH-domain-containing protein overexpressed in cancerdc.subject
KeywordKOCdc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
TitleBedeutung von KH-domain containing protein overexpressed in cancer (KOC) als Marker zur Diagnostik einer Manifestation von malignen Erkrankungen im ZNSdc.title
Resource typeDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-1348dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-61751dc.identifier.urn
GNDAkute myeloische Leukämiedc.subject.gnd
GNDCytologiedc.subject.gnd
GNDLiquordiagnostikdc.subject.gnd
GNDTumormarkerdc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
Date of activation2008-01-16T08:35:42Zuulm.freischaltungVTS
Peer reviewneinuulm.peerReview
Shelfmark print versionZ: J-H 11.756; W: W-H 9.955uulm.shelfmark
DCMI TypeTextuulm.typeDCMI
VTS-ID6175uulm.vtsID
CategoryPublikationenuulm.category
University Bibliographyjauulm.unibibliographie


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