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AuthorWagner-Cakir, Eveline Mariadc.contributor.author
Date of accession2016-03-14T15:21:47Zdc.date.accessioned
Available in OPARU since2016-03-14T15:21:47Zdc.date.available
Year of creation2007dc.date.created
AbstractOBJECTIVES: Ertapenem, a class I carbapenem, is approved for the treatment of mild to severe intraabdominal infections, but its in vivo concentrations in intraabdominal tissues are unknown. The purpose of this study was to determine the concentration of ertapenem in intraabdominal tissue. PATIENTS AND METHODS: After informed consent 48 patients, 23 female and 25 male with a median age of 58 years (34 - 81), requiring surgical intervention at intraabdominal organs were enrolled. Patients received 1 g of ertapenem intravenously for perioperative prophylaxis. Tissue samples were taken after resection of parts of the organs. Plasma samples were taken when tissue samples were taken. Drug concentrations were determined by liquid chromatography/mass spectrometry. An ANCOVA test (analysis of covariance) was performed to assess organ-specific differences in ertapenem concentration and penetration ratios. RESULTS: Mean +/- SD ertapenem tissue concentration (mg/kg) was 16.0 +/- 8.8 in the gall bladder, 12.1 +/- 5.3 in the colon, 7.0 +/- 5.7 in the small bowel, 4.5 +/- 2.3 in the liver and 3.4 +/- 2.9 in the pancreas. The mean tissue/plasma ratio was 0.19 (colon), 0.17 (small bowel), 0.17 (gall bladder), 0.088 (liver) and 0.095 (pancreas). The ANCOVA test revealed statistically significant organ-specific differences in ertapenem tissue concentration in the gall bladder versus liver/pancreas and in tissue penetration for the colon versus liver/pancreas. CONCLUSIONS: These pharmacokinetic results support the assumption that ertapenem is suitable for the treatment of intraabdominal infections.dc.description.abstract
Languagededc.language.iso
PublisherUniversität Ulmdc.publisher
LicenseStandard (Fassung vom 03.05.2003)dc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_v1dc.rights.uri
KeywordTissue concentrationdc.subject
Dewey Decimal GroupDDC 610 / Medicine & healthdc.subject.ddc
MeSHAnti-bacterial agentsdc.subject.mesh
MeSHAntibioticsdc.subject.mesh
MeSHbeta-Lactamsdc.subject.mesh
MeSHErtapenemdc.subject.mesh
TitleIntraabdominelle Gewebekonzentration von Ertapenemdc.title
Resource typeDissertationdc.type
DOIhttp://dx.doi.org/10.18725/OPARU-1303dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-vts-60465dc.identifier.urn
GNDLactamase <beta->dc.subject.gnd
FacultyMedizinische Fakultätuulm.affiliationGeneral
Date of activation2007-10-30T14:23:29Zuulm.freischaltungVTS
Peer reviewneinuulm.peerReview
Shelfmark print versionZ: J-H 11.593 ; W: W-H 9.797uulm.shelfmark
DCMI TypeTextuulm.typeDCMI
VTS-ID6046uulm.vtsID
CategoryPublikationenuulm.category
University Bibliographyjauulm.unibibliographie


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