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The armadillo protein p0071 controls directionality of kinesin-2 driven transport by mediating KIF3 motor complex stability

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BecherADiss2019.pdf (3.703Mb)
Erstveröffentlichung
2019-04-03
Authors
Becher, Alexander
Referee
Tuckermann, Jan
Seufferlein, Thomas
Dissertation


Faculties
Fakultät für Naturwissenschaften
Medizinische Fakultät
Institutions
Institut für Molekulare Endokrinologie der Tiere
UKU. Klinik für Innere Medizin I
Abstract
In this study, a novel and unexpected role of the armadillo repeat protein p0071 in cellular transport is described. P0071 abrogation in cultured cells significantly interferes with secretion of various secretory cargo proteins. This effect is specifically targeting cargo substrates of the microtubule based heterotrimeric kinesin-2 complex, which comprises of KIF3A, KIF3B and KAP3. Impairment of both p0071 and KIF3B leads to aberrant movement of chromogranin A granules in neuroendocrine tumor cells due to impaired directional persistence of vesicle transport. This effect is likely explained by a potential function of p0071 as a stabilizing linker within the kinesin-2 complex since it could be shown that p0071 mediates the interaction between the motor subunit KIF3B and the cargo-adaptor subunit, KAP3.
Date created
2018
Subject headings
[GND]: Kinesin | Proteintransport | Chromogranin A | Metalloproteinasen
[MeSH]: Kinesin | Protein transport | Chromogranin A | Matrix metalloproteinases | Armadillo domain proteins
[Free subject headings]: p0071 | PKP4 | KIF3B | MMP-9
[DDC subject group]: DDC 570 / Life sciences | DDC 610 / Medicine & health
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DOI & citation

Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-13107

Becher, Alexander (2019): The armadillo protein p0071 controls directionality of kinesin-2 driven transport by mediating KIF3 motor complex stability. Open Access Repositorium der Universität Ulm und Technischen Hochschule Ulm. Dissertation. http://dx.doi.org/10.18725/OPARU-13107
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