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AuthorLopez-Lorente, Angela I.dc.contributor.author
AuthorWang, Peidc.contributor.author
AuthorSieger, Markusdc.contributor.author
AuthorCatalan Vargas, Ernestodc.contributor.author
AuthorKarlsson, Mikaeldc.contributor.author
AuthorNikolajeff, Fredrikdc.contributor.author
AuthorÖsterlund, Larsdc.contributor.author
AuthorMizaikoff, Borisdc.contributor.author
Date of accession2019-03-26T13:19:42Zdc.date.accessioned
Available in OPARU since2019-03-26T13:19:42Zdc.date.available
Date of first publication2016-04-28dc.date.issued
AbstractDiamond has excellent optical properties including broadband transmissivity, low self-absorption, and a high refractive index, which have prompted its use for optical sensing applications. Thin- film diamond strip waveguides (DSWGs) combined with tunable quantum cascade lasers (tQCLs) providing an emission wave- length range of 5.78–6.35 mm (1735–1570 cm"1) have been used to obtain mid-infrared (MIR) spectra of proteins, thereby enabling the analysis of their secondary structure via the amide I band. Three different proteins were analyzed, namely bovine serum albumin (BSA), myoglobin, and g-globulin. The secondary structure of BSA and myoglobin has a major contribution of a-helices, whereas g-globulins are rich in b-sheet structures, which is reflected in the amide I band. A comparison of the spectra obtained via the combination of the tQCL and DSWG with spectra obtained using conventional Fourier transform infrared (FTIR) spectroscopy and a commercial diamond attenuated total reflection (ATR) element has been performed. It is shown that the main features evident in FTIR-ATR spectra are also obtained using tQCL-DSWG sensors.dc.description.abstract
Languageen_USdc.language.iso
PublisherUniversität Ulmdc.publisher
Earlier versionhttp://dx.doi.org/10.18725/OPARU-6079dc.relation.isversionof
LicenseStandard (ohne Print-on-Demand)dc.rights
Link to license texthttps://oparu.uni-ulm.de/xmlui/license_opod_v1dc.rights.uri
KeywordDiamonddc.subject
KeywordWaveguidesdc.subject
KeywordInfrared sensorsdc.subject
KeywordQuantum cascade lasersdc.subject
KeywordInfrared Spectroscopydc.subject
KeywordProteinsdc.subject
Dewey Decimal GroupDDC 540 / Chemistry & allied sciencesdc.subject.ddc
LCSHInfrared detectorsdc.subject.lcsh
LCSHInfrared spectroscopydc.subject.lcsh
LCSHProteinsdc.subject.lcsh
LCSHLasersdc.subject.lcsh
LCSHWave guidesdc.subject.lcsh
LCSHDiamondsdc.subject.lcsh
TitleMid-infrared thin-film diamond waveguides combined with tunable quantum cascade lasers for analyzing the secondary structure of proteinsdc.title
Resource typeWissenschaftlicher Artikeldc.type
VersionacceptedVersiondc.description.version
DOIhttp://dx.doi.org/10.18725/OPARU-12426dc.identifier.doi
URNhttp://nbn-resolving.de/urn:nbn:de:bsz:289-oparu-12483-0dc.identifier.urn
GNDInfrarotdetektordc.subject.gnd
GNDInfrarotspektroskopiedc.subject.gnd
GNDProteinedc.subject.gnd
GNDQuantenkaskadenlaserdc.subject.gnd
GNDWellenleiterdc.subject.gnd
GNDDiamantdc.subject.gnd
GNDSekundärstrukturdc.subject.gnd
GNDATR-Technikdc.subject.gnd
FacultyFakultät für Naturwissenschaftenuulm.affiliationGeneral
InstitutionInstitut für Analytische und Bioanalytische Chemieuulm.affiliationSpecific
Peer reviewjauulm.peerReview
DCMI TypeTextuulm.typeDCMI
CategoryPublikationenuulm.category
DOI of original publication10.1002/pssa.201600134dc.relation1.doi
Source - Title of sourcephysica status solidi (a)source.title
Source - Place of publicationWiley-VCH Verlagsource.publisher
Source - Volume213source.volume
Source - Issue8source.issue
Source - Year2016source.year
Source - From page2117source.fromPage
Source - To page2123source.toPage
Source - ISSN0031-8965source.identifier.issn
Source - eISSN1862-6319source.identifier.eissn
EU projectTROPSENSE / Development of a non-invassive breath test for early diagnosis of tropical diseases / EC / H2020 / 645758uulm.projectEU


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