Polymeric nanoparticles synthesized via miniemulsion process as templates for biomimetic mineralization
FacultiesFakultät für Naturwissenschaften
LicenseStandard (Fassung vom 03.05.2003)
In this work, polymeric nanoparticles synthesized via the miniemulsion process are employed as templates for the biomimetic mineralization of hydroxyapatite (the thermodynamically stable form of calcium phosphate) in the aqueous phase. As the versatile miniemulsion technique allows the fabrication of polymeric nanoparticles by the polymerization of respective monomers as well as by using the preformed polymers, the technique was exploited to produce nanoparticles from natural as well as synthetic polymers. While gelatin (a natural polymer) and aliphatic polyesters (synthetic biodegradable polymers) were used as preformed polymers, a copolymer comprising of poly(styrene-co-acrylic acid) was used as a biocompatible polymer for the formulation of nanoparticles. These formulated polymer nanoparticles were subsequently used as templates for the calcium phosphate mineralization in aqueous phase. As the gelatin nanoparticles by themselves have high potential to be used in the pharmaceutical field, the first part of the work deals with the synthesis and optimization of the gelatin nanoparticles using the miniemulsion process. The optimized stable nanoparticles were further used as templates for biomimetic mineralization of calcium phosphate in the second part. While gelatin nanoparticles were used as confined nano-environment to perform crystallization inside the particles, in the third part of the work, the surface-functionalized polymeric nanoparticles (poly(styrene-co-acrylic acid)) were exploited as templates to perform crystallization outside on the surface of the particles. In the fourth part, the polyester based nanoparticles comprising of the anionic functional groups distributed in the nanoparticle matrix were used as templates for calcium phosphate mineralization. The hybrid nanoparticles were characterized using TEM, HRSEM, and XRD. All these composite nanoparticles have high potential for tissue engineering applications.
Subject HeadingsMiniemulsion [GND]
Chemical templates [LCSH]