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Charakterisierung des Glycogen- und Maltosestoffwechsels von Corynebacterium glutamicum

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vts_6381_8590.pdf (2.466Mb)
93 Seiten
Veröffentlichung
2008-05-09
Authors
Seibold, Gerd Michael
Dissertation


Faculties
Fakultät für Naturwissenschaften
Abstract
The Gram-positive soil bacterium Corynebacterium glutamicum transiently accumulates large amounts of glycogen, when cultivated in media with carbohydrates as source of carbon and energy. On a first glance glycogen synthesis in this organism proceeds by the pathway generally known for bacteria by phosphoglucomutase, ADP-glucose-pyrophoshorylase, glycogen synthase and branching enzyme. In fact, presence of this pathway for glycogen synthesis could be confirmed for C. glutamicum cultivated with glucose, whereas glycogen synthesis proceeds in this organism when cultivated with maltose by a so far unknown way. A prerequisite for the investigation of this pathway was the characterization of the so far unknown maltose metabolism of C. glutamicum. It was here shown, that following the uptake by a so far unidentified transporter, maltose is metabolized by 4-a-glucanotransferase, maltodextrin phosphorylase, glucose kinase, phosphoglucomutase and eventually maltodextrin glucosidase. Glycogen degradation in C. glutamicum is also closely linked to maltose metabolism. The degradation thereby generally proceeds by the pathway described for Escherichia coli. Accordingly, maltodextrins are formed from glycogen as intermediates by the action of glycogen phosphorylase and debranching enzyme. These maltodextrins are further degraded to finally glucose-6-phosphate by maltodextrin phosphorylase and phosphoglucomutase, which are also part of maltose metabolism.
Date created
2007
Subject headings
[GND]: Corynebacterium glutamicum | Glykogen | Maltose | Stärke
[LCSH]: Glycogen. Metabolism | Maltose. Metabolism
[DDC subject group]: DDC 570 / Life sciences
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Standard (Fassung vom 03.05.2003)
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DOI & citation

Please use this identifier to cite or link to this item: http://dx.doi.org/10.18725/OPARU-1132

Seibold, Gerd Michael (2008): Charakterisierung des Glycogen- und Maltosestoffwechsels von Corynebacterium glutamicum. Open Access Repositorium der Universität Ulm und Technischen Hochschule Ulm. Dissertation. http://dx.doi.org/10.18725/OPARU-1132
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