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Spreading of amyloid, tau, and microvascular pathology in Alzheimer´s disease: findings from neuropathological and neuroimaging studies
Primary pathologies including amyloid-beta (Abeta) plaques and neurofibrillary tangles (NFT) develop many years before the onset of dementia symptoms in Alzheimer’s disease (AD). Age-related small vessel disease (SVD) is ...
Longitudinal trajectories of metabolic control from childhood to young adulthood in type 1 diabetes from a large German/Austrian registry: A groupbased modelling approach
(Universität Ulm, 2017-03-01)
OBJECTIVE: Worsening of glycemic control in type 1 diabetes during puberty is a common observation. However, HbA1c remains stable or even improves for some youths. The aim is to identify distinct patterns of glycemic ...
Impact of long-term air pollution exposure on metabolic control in children and adolescents with type 1 diabetes: results from the DPV registry
(Universität Ulm, 2018-02-24)
Aims: Studies on the association between air pollution and metabolic control in children and adolescents with type 1 diabetes are rare and findings are inconsistent. We examined the relationship between particulate matter ...
The clinical course of patients with preschool manifestation of Type 1 diabetes is independent of the HLA DR-DQ genotype
(Universität Ulm, 2017-05-19)
Introduction: Major histocompatibility complex class II genes are considered major genetic risk factors for autoimmune diabetes. We analysed Human Leukocyte Antigen (HLA) DR and DQ haplotypes in a cohort with early-onset ...