Now showing items 1-5 of 5
Characterisation of calcium kinetics in muscle cells of mouse models of malignant hyperthermia and central core disease
(Universität Ulm, 2018-06-07)
Malignant hyperthermia (MH) is a potentially lethal pharmacogenetic disorder. Numerous mutations of the ryanodine receptor 1 (RyR1) found in skeletal muscles have been identified to be causative for the susceptibility to ...
Expression analysis of mitochondrial and plasmalemmal calcium transporters in individual hypoglossal motor neurons of endstage superoxide dismutase 1 transgenic mice
(Universität Ulm, 2017-09-27)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting particularly cholinergic motor neurons (MN) of the motor cortex, the brainstem and the spinal cord, and leading to paralysis and atrophy of the ...
Untersuchung der σ-Pore in spannungsabhängigen hKv-Kanälen
(Universität Ulm, 2018-09-03)
Current through the σ-pore was first detected in hKv1.3_V388C channels, where the V388C mutation in hKv1.3 channels opened a new pathway (σ-pore) behind the central α-pore. Typical for this mutant channel was inward current ...
Characterization of the effects of Endophilin A3 on the physiological properties of SK3 channels
(Universität Ulm, 2016-04-25)
Small conductance calcium-activated (SK) channels play an important role by controlling the after-hyperpolarization of excitable cells. The level of expression and density of these channels is an essential factor for ...
The interaction between the voltage-gated potassium channel hKv1.3 and verapamil
(Universität Ulm, 2018-03-28)
T- and B-lymphocytes usually express the human voltage-gated Kv1.3 channel (hKv1.3). Verapamil known as a potent L-type Ca2+channel blocker is also able to block hKv1.3 channels. The blocking effect of verapamil on currents ...