Now showing items 31-40 of 605
Analyse der genetischen Rearrangements an einem Segment der mixed lineage leukemia Bruchpunktregion (MLLbcr) und an DNA-Sequenzen mit Topoisomerase I-Erkennungsstellen
To investigate genetic rearrangements at a segment of the MLL (mixed lineage leukemia) breakpoint cluster region (bcr) a fluorescence based recombination test system was adapted by genetic engineering. Based on the detected ...
Einfluss der Proteine der Basenfehlpaarungsreparatur auf die Reparatur von DNA Doppelstrangbrüchen in Säugern
The human MMR proteins are components of the post-replicative MMR machinery. In procaryotic and lower eucaryotic DSB repair processes MutS and MutL are known to repress exchange between short stretches of homology. Furthermore ...
Optimierung des Einsatzes von Blei-Säure-Akkumulatoren in Photovoltaik-Hybrid-Systemen unter spezieller Berücksichtigung der Batteriealterung
Lead-acid batteries are widely used in off-grid and stand-alone power supply systems. In many cases these systems are powered by photovoltaics and wind turbines. The battery is necessary for levelling energy supply and ...
Transition metal-catalyzed nucleophilic substitution at thiophene-halides
Task of this thesis was nucleophilic substitution at thiophene-halides with O- and N-nucleophiles using copper and palladium catalysts. It was shown that phenols could be coupled under mild reactions conditions using modern ...
Charakterisierung intrinsischer Eigenschaften eines Propriozeptors und deren Beitrag zur sensorischen Informationsverarbeitung
Interaction with the environment is an important part of animal behavior. Sensory feedback provides necessary information for the body to generate an adequate behavior. The cellular properties and their importance for ...
Area in phase space as determiner of transition probability: Bohr-Sommerfeld bands, Wigner ripples, and Fresnel zones
Dynamic investigation of polymeric materials: reproducible data acquisition and profound mechanical analysis
By means of the Atomic Force Microscope (AFM), the mechanical properties at nanoscale dimensions can be accessed. Theories and simulations describing these nano-mechanics, however, are not yet conclusive. The reliable and ...
Nuclear Factor-kappaB signaling pathway controls a pro-inflammatory and pro-atherogenic gene expression program in endothelial cells
Activation of the transcription factor NF-kappaB is a critical step for tumor necrosis factor-alpha-induced inflammatory response. In the present study human microvascular endothelial cell line-1 cells were modified to ...
Mechanismen der Regulation des pca-qui-Operons aus dem Bakterium Acinetobacter baylyi Stamm ADP1
Acinetobacter baylyi is able to utilize aromatic compounds via the ß-ketoadipate-pathway which consists of two branches. This study focusses on the protocatechuate branch whose enzymes are encoded by the pca genes. The ...
Nitrogen regulation of transport operons: analysis of promoters argTr and dhuA