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Proinsulin 74-90 basierende proteaseresistente Peptidliganden erhöhen die TGF-ß1 Sekretion in humanen peripheren mononukleären Zellen von Typ 1 Diabetes mellitus Patienten
Dissertation
Proinsulin is a major diabetes-associated autoantigen. The proinsulin based sequence 74-90 (P17), a t-cell epitope, which activates autoaggressive T-cells, was used to generate protease-resistant altered peptide ligands ...