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Development of enhanced analytical methods for ultratrace determination of mercury in natural water
(Universität Ulm, 2017-08-15)
Mercury (Hg) is a ubiquitous pollutant that is emitted to the atmosphere from both anthropogenic and natural sources. Human exposure to Hg occurs mainly from consumption of contaminated fish, as Hg exhibits very high ...
Aggregation during biopharmaceutical production of antibodies induced by UV radiation and interface exposure
(Universität Ulm, 2017-05-05)
In the manufacturing process of therapeutic monoclonal antibodies (mAbs) aggregate formation is a crucial problem. Proteins tend to aggregate due to several stress conditions during processing and storage. This may reduce ...
Thin-film waveguide technology towards mid-infrared lab-on-chip systems
(Universität Ulm, 2017-05-12)
This cumulative thesis focuses on the development of thin-film waveguide technologies and their application for chem/bio sensors in food and feed quality monitoring scenarios. The thesis is based on seven peer-reviewed ...
Protein aggregation during bioprocessing of monoclonal antibodies in mammalian cell culture
(Universität Ulm, 2017-02-23)
Monoclonal antibodies (mAbs) are successful biopharmaceuticals playing an important role in the treatment of cancer, autoimmunity and inflammatory diseases. Mammalian cells are the dominant system for the recombinant ...
Development of selective sorbent materials for the determination of polychlorinated biphenyls (PCBs) in the environment
(Universität Ulm, 2016-11-21)
In this thesis, synthesis of molecularly imprinted polymers with molecular recognition for polychlorinated biphenyls (PCBs) as well as the application of the polymers as pre-concentration and clean-up sorbents in the ...
Design and synthesis of submicron polymer particles for the selective capture of proteases
(Universität Ulm, 2017-03-07)
The design of biomimetic synthetic receptors capable of mimicking the molecular recognition properties of antibodies is of significant interest for the application in many analytical methods. The selective binding of ...
Mid-infrared sensors for environmental monitoring
(Universität Ulm, 2017-01-20)
The presented cumulative thesis is focused on the development of mid-infrared sensors and their application in environmental monitoring scenarios. This thesis is based on five peer-reviewed journal articles, and includes ...
Advanced electrochemical analysis: boron-doped diamond electrodes, electrocatalytic films, and combined SECM - SPR
(Universität Ulm, 2018-03-09)
Today’s analytical demands are driven by complex questions arising from various fields ranging from analysis in life sciences to material sciences involving surface modifications at the nano- to micrometer scale. Based on ...
Chemical and structural analysis of Xylella fastidiosa biofilm formation
(Universität Ulm, 2018-03-20)
Xylella fastidiosa (Xf) is a gram-negative phytopathogen bacterium that affects the xylem vessels of citrus, olives, grapevines, coffee, almonds among many other plants by vascular occlusion [1–3]. Diseases such as citrus ...
A novel chemometric classification for FTIR spectra of mycotoxin-contaminated maize and peanuts at regulatory limits
(Universität Ulm, 2016)
The rapid identification of mycotoxins such as deoxynivalenol and aflatoxin B1 in agricultural commodities is an ongoing concern for food importers and processors. While sophisticated chromatography-based methods are well ...