Robust parahydrogen-induced polarization at high concentrations
Loading...
Date
2024-07-24
Authors
Dagys, Laurynas
Korzeczek, Martin C.
Parker, Anna J.
Eills, James
Blanchard, John
Bengs, Christian
Levitt, Malcolm
Knecht, Stephan
Schwartz, Ilai
Plenio, Martin B.
Journal Title
Journal ISSN
Volume Title
Publication Type
Wissenschaftlicher Artikel
Published in
Science Advances, 2024
Abstract
Parahydrogen-induced
polarization (PHIP) is a potent technique for generating target molecules with high nuclear
spin polarization. The PHIP process involves a chemical reaction between parahydrogen and a target molecule,
followed by the transformation of nuclear singlet spin order into magnetization of a designated target nucleus
through magnetic field manipulations. Although the singlet-to-
magnetization
polarization transfer process works
effectively at moderate concentrations, it is observed to become much less efficient at high molar polarization,
defined as the product of polarization and concentration. This strong dependence on the molar polarization is
attributed to interference due to the field produced by the sample magnetization during polarization transfer,
which leads to complex dynamics and can severely affect the scalability of the technique. We address this challenge
with a pulse sequence that suppresses the influence of the distant dipolar field, while simultaneously
achieving singlet-to-
magnetization
polarization transfer to the desired target spins, free from restrictions on the
molar polarization.
Description
Faculties
Fakultät für Naturwissenschaften
Institutions
Institut für Theoretische Physik
Center for Integrated Quantum Science and Technology (IQST)
Center for Integrated Quantum Science and Technology (IQST)
Citation
DFG Project uulm
EU Project THU
HyperQ / Quantum hyperpolarisation for ultrasensitive nuclear magnetic resonance and imaging / EC / H2020 / 856432
Other projects THU
License
CC BY 4.0 International
Is version of
Has version
Supplement to
Supplemented by
Has erratum
Erratum to
Has Part
Part of
DOI external
DOI external
10.1126/sciadv.ado0373
Institutions
Periodical
Degree Program
DFG Project THU
item.page.thu.projectEU
item.page.thu.projectOther
Series
Keywords
PHIP, Magnetization, Polarization (Nuclear physics), DDC 530 / Physics