Immunogenetic-pathogen networks shrink in Tome’s spiny rat, a generalist rodent inhabiting disturbed landscapes
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Date
2024-02-10
Authors
Fleischer, Ramona
Eibner, Georg Joachim
Schwensow, Nina Isabell
Pirzer, Fabian
Paraskevopoulou, Sofia
Mayer, Gerd
Corman, Victor Max
Drosten, Christian
Wilhelm, Kerstin
Heni, Alexander Christoph
Journal Title
Journal ISSN
Volume Title
Publication Type
Wissenschaftlicher Artikel
Published in
Communications Biology, 2024
Abstract
Anthropogenic disturbance may increase the emergence of zoonoses. Especially generalists that cope with disturbance and live in close contact with humans and livestock may become reservoirs of zoonotic pathogens. Yet, whether anthropogenic disturbance modifies host-pathogen co-evolutionary relationships in generalists is unknown. We assessed pathogen diversity, neutral genome-wide diversity (SNPs) and adaptive MHC class II diversity in a rodent generalist inhabiting three lowland rainforest landscapes with varying anthropogenic disturbance, and determined which MHC alleles co-occurred more frequently with 13 gastrointestinal nematodes, blood trypanosomes, and four viruses. Pathogen-specific selection pressures varied between landscapes. Genome-wide diversity declined with the degree of disturbance, while MHC diversity was only reduced in the most disturbed landscape. Furthermore, pristine forest landscapes had more functional important MHC–pathogen associations when compared to disturbed forests. We show co-evolutionary links between host and pathogens impoverished in human-disturbed landscapes. This underscores that parasite-mediated selection might change even in generalist species following human disturbance which in turn may facilitate host switching and the emergence of zoonoses.
Description
Faculties
Fakultät für Naturwissenschaften
Institutions
Institut für Evolutionsökologie und Naturschutzgenomik
Citation
DFG Project uulm
SPP 1596 Teilprojekt / Prozesse und Mechanismen der Zunahme und Diversifizierung von Viren im Wildtierreservoir: Integration von Wirts- und Virusmerkmalen in Landschaften unterschiedlicher anthropogener Störung / DFG / 226351195 [SO 428/9-1, SO 428/9-2]
EU Project THU
Other projects THU
License
CC BY 4.0 International
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DOI external
DOI external
10.1038/s42003-024-05870-x
Institutions
Periodical
Degree Program
DFG Project THU
item.page.thu.projectEU
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Series
Keywords
Ecological genetics, Evolutionary biology, DDC 590 / Animals (Zoology)